Amber Flores of Calexico opened the top of the first inning with a double to left field.
Jonathan Arellano hit a single that plated Amber Flores and Calexico took a 1-0 lead into the second.
Amber Flores faced Holtville pitcher James Bentley once again in the second, but catcher Adam Anderholt interfered with her bat and she walked with the bases loaded to add one run to the Calexico advantage.
Arellano opened the third with a home run and two more runs scored in the inning to push Calexico to a 5-0 lead.
In the fourth, Calexico again extended its lead when Ivan Rodriguez scored on an error and Arellano drove in Daniel Flores with a single to build a 7-0 lead.
The final three runs came in the sixth when Ralph Solano was driven in by Shaun Grady with a single and Stephen Caesar and Grady were sent home by Amber Flores with a two-run double to left field.
Daniel Flores struck out Holtville's Javier Fregoso for the game's final out.
The win propels Calexico into the final round of the tournament to face unbeaten Imperial.
"We know Imperial's tough," Carrillo said. "They've got a real strong team."
He added that to face Imperial, Calexico's good pitching is going to have to continue.
"We're going to come back with some strong pitching," Carrillo said. "Good pitching beats good hitting," he added, conceding that Imperial has some strong hitters.
"I feel we have a good team," Carrillo said. "I feel we have a chance."
Calexico, which has won four consecutive must-win games, will likely face the pitching of Imperial's ace, Brock Moore.
"We have already faced him in the inter-city (tournament), so we know how he throws,"
said Daniel Flores. "If we don't hit, we don't win."
Carrillo said he admires the coaching of Imperial's Alfred Moore and he expects a close game.
"We've had our backs against the wall for four games," Carrillo said. "Every game we've won, we had to win."
Holtville was eliminated from the tournament with the loss.
Calexico will face Imperial in the final round Monday in Seeley at 7:30. To win the championship, Calexico must beat Imperial twice because of the double-elimination format.
Imperial only needs one victory to claim the tournament.