You bet right! You can catch a bus or buy a ticket at the Central de Autobuses de Mexicali (Central bus station) on the corner of Calzada Independencia y Avenida de Anahuac. Or you can dial directly 011526865-06-04.
Or take another route, call the Comite de turismo y Convenciones de San Felipe. The phone number is 011526865772300.
You can get by with a handful of words of Spanish but it helps if you know more. If you can, take a Spanish speaking friend with you because Mexican bus travel offers a lot of choices.
You can buy your tickets in advance and choose from first class, second, or even third class service. Overall, Mexican bus service is better than American service. People still ride buses below the border.
We've taken the bus a couple of times. The first time, we had to complete a trip to Guadalajara on a bus after our train derailed west of Tepec. The last time, we chose the bus for the trip between Mexicali and Mazatlan. It took 28 hours but was considerably more comfortable than the train.