"They're part of our pride and joy," Pineiro said.
The Lyon brothers almost won another set, against La Jolla's No. 2 duo of Mark Chen and Bruce Chen, losing 6-4.
The Lyons fell to La Jolla's No. 1 team Conner Schiller and J.B. Schiller 6-1.
Southwest's No. 2 doubles team of John Bonano and Timm Walter almost downed Hou and Wu, losing 7-5. Bonano and Walter lost to the Chen brothers 6-1 and the Schiller pair 6-1.
The Eagles' No. 3 pair of Bobby Romero and Jared Kaye fell to the Schillers 6-1, the Chens 6-1 and to Hou and Wu 6-0.
Singles play was something altogether different.
Southwest's No. 1 Kareem Salem, No. 2 Idrees Saliman and No. 3 Hector Bravo were all swept 6-0.
Representing La Jolla were No. 1 Brandon Wai, No. 2 Eric Ruebens and No. 3 Blake Zacharias.
"This team is one of the best teams in Southern California," said La Jolla head coach Raymond Bos. "Our singles players are very strong. I expected we may lose a few games. We lost one in doubles, but they're not our strongest players."
The No. 1-ranked Vikings were granted a bye in the first round and did not have to travel, while No. 8 Southwest had to host a first-round match the previous day before traveling two hours for Wednesday's event.
"The seeding could have been a little bit better," said Pineiro, whose Eagles faced these Vikings a couple weeks ago in a friendly match with similar results. "Realistically these guys are a step above everyone."
The Eagles were without their top singles player Mike Palacios, who was ineligible.
Next the Eagles are looking forward to the CIF individual competition, where they will have a number of competitors, including the Lyon brothers.
The loss wraps the Eagles' season at 14-2, including an Imperial Valley League title, their fifth in seven years.
"We got the boys back on a winning track," Pineiro said. "Got them used to winning again. The tennis program is going really well."